Innocent VIII never lived up to his name. He's known mostly for corruption: selling off church offices, marrying his illegitimate children into the Medici family (he paid by giving a cardinalship to the bride's thirteen-year-old brother!), and so forth. Supposedly he had sixteen children.

There's also a story - thankfully unsubstantiated - that three young boys died while transfusing blood to Innocent VIII. Wow!